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This review aims to evaluate the complex roles of BAFF in systemic lupus erythematosus, particularly its interaction with regulatory B cells.

July 23, 2026DrugsOpen Access

Balancing Act: The Dual Roles of BAFF in Systemic Lupus Erythematosus

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Review explores BAFF's impact on immune responses and regulatory B cell function in SLE, suggesting new therapeutic insights.

This review aims to evaluate the complex roles of BAFF in systemic lupus erythematosus, particularly its interaction with regulatory B cells.
Examines the role of BAFF and APRIL in B cell regulation through their receptors in SLE.
Analyzes clinical trial data on anti-BAFF therapies and their effects on disease activity and B cell survival.
Highlights evidence of BAFF's impact on regulatory B cell function and cytokine levels.
Belimumab resulted in significant improvement of overall disease activity in SLE, but cases of de novo lupus nephritis occurred.
Anti-BAFF therapies showed variable safety profiles with profound suppression of immunoglobulin production and B cell survival.
Decline in IL-10 levels and B cell populations expressing regulatory markers observed after belimumab initiation.

Alvarez‐Gómez et al. (2026) studied this question.

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