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This study aims to explore how psychometric, biochemical, and genetic parameters of serotonin and dopamine correlate with violent criminal behavior.

Association of monoamine system parameters with violent criminal behavior

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Randomized trial assesses how serotonin and dopamine factors relate to violent crime, highlighting neurobehavioral markers.

This study aims to explore how psychometric, biochemical, and genetic parameters of serotonin and dopamine correlate with violent criminal behavior.
Included male participants without criminal records (N=110) and those who committed violent crimes (N=143).
Administered the Buss-Perry questionnaire for aggression and analyzed urine for monoamine metabolites 5-HIAA and HVA.
Performed genetic genotyping for HTR2A rs6313 and DRD4 rs1800955 polymorphisms.
Offenders showed higher aggression levels and lower concentrations of 5-HIAA and HVA compared to controls.
Total BPAQ scores (B = 0.047; p < 0.001), HVA levels (B = -0.004; p < 0.001), and STQ-77 Empathy (B = 0.225; p = 0.004) were independent markers of violent behavior.
Overall classification accuracy for the model was 86.1%.

Peregud et al. (2026) studied this question.

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