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July 23, 2026Journal of Biochemical and Molecular ToxicologyOpen Access

Nano‐Rosmarinic Acid Protects Against Chlorfenapyr‐Induced Testicular Toxicity Through Modulation of NRF2/HO‐1 and NF‐κB/NLRP3 Signaling Pathways

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Authors

AAAhmad Najem AlshammariAAAyat B. Al‐GhafariHDHuda A. Al Doghaither

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Overview

Randomized trial investigates protection against reproductive damage in male rats, suggesting enhanced efficacy of nano-encapsulation strategy.

Key Points

  • This study aims to uncover molecular mechanisms of chlorfenapyr-induced testicular toxicity and assess whether nano-rosmarinic acid can ameliorate these effects.
  • 60 adult male Wistar rats were divided into six groups and treated with various doses of chlorfenapyr and/or rosmarinic acid for 30 days.
  • Immunohistochemical analysis evaluated NF-kB and NLRP3 expression in testes.
  • Oxidative stress, hormone levels, and sperm parameters were measured to assess reproductive damage.
  • CFP exposure led to reduced testicular weight, sperm count, and reproductive hormone levels, indicating significant reproductive toxicity.
  • Co-administration of RA-CHNPs markedly improved testicular architecture and normalized hormone levels compared to crude RA.
  • RA-CHNPs suppressed NF-kB and NLRP3 signaling while activating the NRF2/HO-1 antioxidant pathway, demonstrating superior protective effects.

Cite This Study

Alshammari et al. (2026) studied this question.

synapsesocial.com/papers/6a61af56faa9903c5116a2d8https://doi.org/10.1002/jbt.71037
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