What question did this study set out to answer?

The aim was to evaluate the association between diabetic foot ulcers and mortality in individuals with diabetes and heart failure.

July 23, 2026Diabetes Obesity and Metabolism

Diabetic Foot Ulcers Are Clinical Marker of Disease Burden in People With Diabetes and Heart Failure

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AAAfram AkturkZiekenhuis Groep Twente GLG C M LinssenZiekenhuis Groep Twente JNJ. J. van NettenQueensland University of Technology

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Implication

Retrospective cohort study evaluates mortality and hospitalizations in diabetes and heart failure linked to diabetic foot ulcers, indicating disease burden implications.

Key Points

The aim was to evaluate the association between diabetic foot ulcers and mortality in individuals with diabetes and heart failure.
Conducted a retrospective cohort study from 2002 to 2021 at a single center in the Netherlands.
Included 4937 adults with diabetes and heart failure, stratified by diabetic foot ulcer status.
Used multivariable Cox regression and a time-varying Cox model to analyze outcomes.
32.0% mortality at 5 years for diabetic foot ulcer group vs. 25.1% for non-ulcer group (p < 0.001).
1-year mortality of 32.9% in the ulcer group vs. 6.0% in the non-ulcer group (p < 0.001).
Time-varying analysis showed HR 2.88 (95% CI 2.26–3.66; p < 0.001) for mortality associated with diabetic foot ulcers.

Cite This Study

Akturk et al. (2026) studied this question.

synapsesocial.com/papers/6a61af8bfaa9903c5116a55d https://doi.org/10.1111/dom.71121

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Implication

Retrospective cohort study evaluates mortality and hospitalizations in diabetes and heart failure linked to diabetic foot ulcers, indicating disease burden implications.

Diabetic Foot Ulcers Are Clinical Marker of Disease Burden in People With Diabetes and Heart Failure

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Implication

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Cite This Study

Diabetic Foot Ulcers Are Clinical Marker of Disease Burden in People With Diabetes and Heart Failure

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Implication

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Cite This Study

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