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This review evaluates whether autism spectrum disorder and neurodegenerative diseases are distinct or linked through shared mechanisms.

July 23, 2026Brain SciencesOpen Access

Autism and Neurodegeneration: Distinct Disorders or a Shared Biological Continuum?

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Narrative review evaluates shared biological mechanisms in autism spectrum disorder and neurodegenerative diseases, suggesting a continuum.

This review evaluates whether autism spectrum disorder and neurodegenerative diseases are distinct or linked through shared mechanisms.
Synthesis of findings from genetic, molecular, cellular, circuit-level, and epidemiological studies.
Examination of major neurodegenerative conditions, including Alzheimer's disease, Parkinson's disease, and Amyotrophic lateral sclerosis.
Focus on identifying convergent pathways within a lifespan-oriented framework.
ASD and neurodegenerative diseases share overlapping biological mechanisms such as mitochondrial dysfunction and impaired proteostasis.
Epidemiological data indicate increased risk of dementia and parkinsonian features in autistic adults.
Circuit-level studies highlight shared vulnerabilities, including cerebellar involvement and excitation–inhibition imbalance.

Manzo et al. (2026) studied this question.

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July 23, 2026Brain SciencesOpen Access

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Authors

Narrative review evaluates shared biological mechanisms in autism spectrum disorder and neurodegenerative diseases, suggesting a continuum.

This review evaluates whether autism spectrum disorder and neurodegenerative diseases are distinct or linked through shared mechanisms.
Synthesis of findings from genetic, molecular, cellular, circuit-level, and epidemiological studies.
Examination of major neurodegenerative conditions, including Alzheimer's disease, Parkinson's disease, and Amyotrophic lateral sclerosis.
Focus on identifying convergent pathways within a lifespan-oriented framework.
ASD and neurodegenerative diseases share overlapping biological mechanisms such as mitochondrial dysfunction and impaired proteostasis.
Epidemiological data indicate increased risk of dementia and parkinsonian features in autistic adults.
Circuit-level studies highlight shared vulnerabilities, including cerebellar involvement and excitation–inhibition imbalance.

Manzo et al. (2026) studied this question.

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