Key result
Cardioneuroablation resolves symptoms in a patient with severe nocturnal vagal hyperreactivity by restoring autonomic balance.
Why the study?
Cardioneuroablation is an emerging option for cardioinhibitory syncope, but its role after pacemaker implantation has been rarely reported.
Does cardioneuroablation improve symptoms and reduce pacemaker rate-drop responses in a patient with vagal hyperreactivity unmasked after pacemaker implantation?
Population
One 43-year-old man with recurrent syncope from sinus arrest developing nocturnal vagal hyperreactivity after pacemaker implantation
Design
Case report
Authors
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CNA may be feasible post-pacemaker in vagal asystole; leaves open patient selection and long-term outcomes.
Case Report (n=1)
Does cardioneuroablation improve symptoms and reduce pacemaker rate-drop responses in a patient with vagal hyperreactivity unmasked after pacemaker implantation?
Cardioneuroablation can successfully restore autonomic balance and resolve debilitating symptoms in patients with severe vagal hyperreactivity unmasked by pacemaker implantation.
Mohammed et al. (2026) conducted a case report in Recurrent syncope due to prolonged sinus arrest and vagal hyperreactivity (n=1). Cardioneuroablation was evaluated on Suppression of nocturnal vagal episodes and symptomatic improvement. Cardioneuroablation successfully restored autonomic balance, reduced pacemaker rate-drop responses, and resolved symptoms in a patient with severe nocturnal vagal hyperreactivity.
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