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This review assesses the diagnostic performance of serum amylase and lipase levels in identifying blunt pancreatic trauma in adults.

The association between pancreatic enzyme serum concentrations and blunt pancreatic trauma: a systematic review

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Systematic review evaluates serum enzyme performance for detecting blunt pancreatic trauma in adults, suggesting improved analysis timing.

This review assesses the diagnostic performance of serum amylase and lipase levels in identifying blunt pancreatic trauma in adults.
Systematic review of databases including MEDLINE, Embase, Scopus, and Cochrane Central.
Inclusion of observational studies with diagnostic accuracy or clinical outcomes related to serum enzymes.
Risk of bias assessed using the Newcastle-Ottawa Scale.
Four studies included, analyzing 4937 patients with blunt abdominal trauma and 150 with pancreatic injuries.
Early serum amylase measurement showed low sensitivity; however, testing after 3 hours improved accuracy.
Combined serum amylase and lipase testing suggested 85% sensitivity and 100% specificity.

Sykes et al. (2026) studied this question.

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Systematic review evaluates serum enzyme performance for detecting blunt pancreatic trauma in adults, suggesting improved analysis timing.