Key result
Genetic variants in HLA, immune checkpoint, and structural pathways drive autoimmune myocarditis susceptibility and progression.
Why the study?
Recent genomic advances have identified key loci and pathways in autoimmune myocarditis, prompting a synthesis of genetic determinants and their implications for risk stratification and precision medicine.
This review highlights the critical role of genetic determinants, including HLA variants, immune checkpoint genes, and structural proteins, in the pathogenesis and risk stratification of autoimmune myocarditis.
May inform genetic risk stratification in autoimmune myocarditis; extends candidate gene studies but remains hypothesis-generating for precision approaches.
Autoimmune myocarditis is an inflammatory disease of the myocardium driven by immune dysregulation and genetic predisposition. Recent advances in genomics, including genome-wide association studies (GWAS), have revealed key loci and pathways involved in disease susceptibility. This review synthesizes current knowledge on genetic determinants, from classical candidate genes to emerging GWAS findings, and explores their clinical implications for risk stratification and precision medicine.
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Pirzadah et al. (2026) conducted a review in Autoimmune myocarditis. Genetic determinants (HLA variants, non-MHC checkpoint pathways, structural cardiac proteins) was evaluated. Genetic factors, including HLA variants, non-MHC checkpoint pathways, and structural cardiac proteins, play a crucial role in the susceptibility and progression of autoimmune myocarditis.
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