What does this research mean for the field?

Myocarditis is influenced by genetic factors, with specific gene variants linked to its susceptibility and phenotypic variability. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim is to examine the genetic factors contributing to myocarditis and its relationship with inherited cardiomyopathies.

March 13, 2026CardiogeneticsOpen Access

Exploring the Genetic Architecture of Myocarditis and Inherited Cardiomyopathies

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Key result

Desmosomal variants like DSP and PKP2 are linked to recurrent myocarditis evolving into arrhythmogenic cardiomyopathy.

Why the study?

Although traditionally regarded as exclusively immune-mediated, recent evidence highlights the significant role of underlying genetics on susceptibility, phenotypic variability, and long-term prognosis in myocarditis.

Design

Narrative review

Authors

SKSukruth Pradeep KundurKing's College London AMAli Hafeez MalikKing's College London RMRasi MizoriKing's College London

Discussion

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Implication

Supports genetic evaluation in recurrent myocarditis; challenges immune-mediated paradigm and extends ACM genetic predisposition.

Key Points

The aim is to examine the genetic factors contributing to myocarditis and its relationship with inherited cardiomyopathies.
Reviewed literature on genetic factors in myocarditis and cardiomyopathies.
Integrated findings from molecular, imaging, and clinical studies.
Analyzed impacts of specific genetic variants on myocardial conditions.
Certain genetic variants are linked to higher susceptibility to recurrent myocarditis.
Truncating variants in titin and Filamin C are associated with specific disease phenotypes.
Mutations in LMNA, DES, and BAG3 influence inflammatory myocardial remodeling.

Cite This Study

Kundur et al. (2026) studied this question. Variants in desmosomal genes like DSP and PKP2 are linked to recurrent myocarditis that can evolve into arrhythmogenic cardiomyopathy, indicating a genetic predisposition.

synapsesocial.com/papers/69b3abe702a1e69014ccd33e https://doi.org/10.3390/cardiogenetics16010004

Topics

Myocarditis Cardiomyopathy Cardiac amyloidosis

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Exploring the Genetic Architecture of Myocarditis and Inherited Cardiomyopathies

Discussion

Member takes

Implication

Key Points

Cite This Study

Topics

Exploring the Genetic Architecture of Myocarditis and Inherited Cardiomyopathies

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Topics

Also Consider