What question did this study set out to answer?

The study aims to enhance light sheet fluorescence microscopy for imaging biological specimens at air-liquid interfaces.

July 23, 2026npj ImagingOpen Access

Adapting upright light sheet fluorescence microscopy for imaging at air-liquid interface

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This randomized trial demonstrates advanced imaging techniques at the air-liquid interface, highlighting new biological applications.

The study aims to enhance light sheet fluorescence microscopy for imaging biological specimens at air-liquid interfaces.
Developed a device for imaging on an upright light sheet microscope with dipping objectives.
Tested the device on various biological specimens, including embryonic mouse salivary glands and Drosophila brains.
Provided a versatile blueprint for adapting the system to other microscopy designs.
Successfully demonstrated imaging capacity for ex vivo embryonic mouse salivary glands using LSFM.
Achieved effective visualization of human epidermal equivalent cultures at air-liquid interfaces.
Enabled in vivo imaging of adult Drosophila melanogaster brains, showcasing system versatility.

Hobson et al. (2026) studied this question.

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