Key result
Obesity is linked to worse glycemic and lipid profiles in patients with T2D and hypothyroidism.
Why the study?
This study aimed to assess the effects of obesity on lipid profiles, glycemic control, and thyroid function in individuals with type 2 diabetes mellitus and hypothyroidism.
Does obesity affect lipid profiles, glycemic control, and thyroid function in patients with type 2 diabetes mellitus and hypothyroidism?
Cross-Sectional (n=154)
Does obesity affect lipid profiles, glycemic control, and thyroid function in patients with type 2 diabetes mellitus and hypothyroidism?
p-value: p=<0.05
Coexisting diabetes, hypothyroidism, and obesity are associated with compromised glycemic control, lipid profile alterations, and thyroid dysfunction, highlighting the need for comprehensive metabolic assessment.
Obesity may worsen metabolic parameters in T2DM with hypothyroidism; leaves open causal effects and need for interventional trials.
Insufficient physical activity, poor dietary practices, escalating stress levels, and environmental factors are all contributors to the swift rise in obesity, type 2 diabetes mellitus (T2DM), and hypothyroidism worldwide. This study aimed to assess the effects of obesity on lipid profiles, glycemic control, and thyroid function in individuals with T2DM and hypothyroidism. The study included 154 participants: 100 T2DM patients with hypothyroidism and 54 healthy controls. Anthropometric measurements were collected, and biochemical tests, including fasting blood glucose (FBG), hemoglobin A1c (HbA1c), lipid profiles, and thyroid hormone levels; thyroid-stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) were performed. The groups differed significantly (p < 0.05) in age, body mass index (BMI), FBG, HbA1c, TSH, FT3, total cholesterol, and triglycerides. Compared to patients without obesity and controls, diabetic patients with obesity showed higher levels of FBG, HbA1c, cholesterol, triglycerides, and more notable changes in thyroid hormones. Age, FBG, HbA1c, and total cholesterol were found to be significant predictors of obesity by receiver operating characteristic (ROC) curve analysis. The results demonstrate that people suffering from coexisting diabetes, hypothyroidism, and obesity present compromised glycemic control, lipid profile alterations, and thyroid dysfunction. This identifies a metabolic assessment as a primary tool in the management of obese diabetics.
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Naif et al. (2026) conducted a cross-sectional in Type 2 diabetes mellitus and hypothyroidism (n=154). Obesity vs. Patients without obesity and healthy controls was evaluated on Differences in age, BMI, FBG, HbA1c, TSH, FT3, total cholesterol, and triglycerides (p=<0.05). Obesity in patients with type 2 diabetes and hypothyroidism was associated with significantly higher fasting blood glucose, HbA1c, cholesterol, and triglycerides (p < 0.05).
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