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July 23, 2026Advanced Healthcare Materials

Covalent “Locking” of Prodrug Nanoassemblies via Thiol‐Ene Click Crosslinking for Potent Antitumor Therapy

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Authors

XLXuan LiLLLi LiYZYingjie Zhao

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Overview

Randomized trial demonstrates improved antitumor efficacy in tumor-selective prodrug nanoassemblies, suggesting a novel delivery strategy.

Key Points

  • Explore the development of covalently crosslinked prodrug nanoassemblies to enhance stability and antitumor effectiveness.
  • Prodrugs conjugated with cabazitaxel designed using tri-alkene side chains via redox-responsive bonds.
  • Nanoassemblies were constructed and reinforced through thiol-ene click crosslinking with tetra-arm thiol crosslinkers.
  • Evaluation of systemic circulation, tumor accumulation, and antitumor efficacy of the reinforced nanoassemblies.
  • Covalently crosslinked prodrug nanoassemblies showed improved stability compared to noncovalent versions.
  • Enhanced systemic circulation and increased accumulation in tumors were observed.
  • Superior antitumor efficacy was noted with reduced systemic toxicity compared to cabazitaxel alone.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a61b056faa9903c5116aef7https://doi.org/10.1002/adhm.71453
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