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September 10, 2025PharmaceuticsOpen Access

Redox-Responsive π-Conjugated Prodrug Nanoassemblies for Cancer Chemotherapy

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Authors

SLShuwei LiuShenyang Pharmaceutical UniversityLCLiuhui ChenShenyang Pharmaceutical UniversityHZHongyuan ZhangShenyang Pharmaceutical University

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Implication

Observational analysis shows significant antitumor efficacy in 4T1 cancer models, indicating improved delivery with redox-responsive prodrug nanoassemblies.

Key Points

  • FBD nanoassemblies achieved 101.7-fold greater tumor accumulation compared to controls.
  • Optimal redox-responsive release kinetics were found in FBD prodrug structures.
  • Characterization revealed that π-conjugated disulfide bonds influence self-assembly and drug release.
  • FBD nanoassemblies produced significantly smaller tumor volumes than all comparator groups.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68c18c169b7b07f3a0614fbfhttps://doi.org/10.3390/pharmaceutics17091162
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