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Experimental method demonstrates effective amide synthesis in peptides, suggesting a new approach to chemistry.
-butyl)-1,1,3,3-tetramethylguanidine at room temperature gave corresponding amides or dipeptides (almost without epimerization) in excellent yields. Therefore, the present method provides a novel and useful strategy for the synthesis of amides and peptides.
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Zhang et al. (2026) studied this question.
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