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Zearalenone (ZEN) is a non-steroidal estrogenic mycotoxin that extensively contaminates feed and feed ingredients, posing a significant threat to animal health and food safety. Enzymatic degradation of ZEN is regarded as a promising strategy due to its high efficiency and safety. This review provides a comprehensive summary of recent advances in ZEN-degrading enzymes from a novel perspective, encompassing the types and catalytic mechanisms for characterizing ZEN-degrading enzymes, the methods for mining ZEN-degrading enzymes, the strategies for improving ZEN-degrading enzymes, and the applications of ZEN-degrading enzymes. The objective of this review is to offer a reliable reference framework for the enzymatic detoxification of ZEN in feed and feed ingredients, as well as to provide insights for mining other mycotoxin degrading enzyme in the future.
Tang et al. (Thu,) studied this question.