Key result
Leadless pacemakers had a similar successful implantation rate to transvenous pacemakers (RR 1.00; P=0.77), but were associated with lower rates of major complications (RR 0.47; P=0.01).
Why the study?
The study was conducted to compare the effectiveness and examine the safety of leadless pacemakers compared with transvenous pacemakers.
Does leadless pacemaker implantation improve safety and maintain efficacy compared to transvenous pacemakers in patients undergoing single-chamber pacemaker implantation?
Meta-Analysis
Does leadless pacemaker implantation improve safety and maintain efficacy compared to transvenous pacemakers in patients undergoing single-chamber pacemaker implantation?
Relative Risk: 1
p-value: p=0.77
Leadless pacemakers offer similar implantation success rates to transvenous pacemakers while significantly reducing the risk of major complications, infections, and tamponade.
Supports preferring leadless pacemakers to reduce infection and tamponade; extends pooled evidence from 10 studies for single-chamber pacing.
This study aims to compare the effectiveness of leadless pacemakers (LPs) and transvenous pacemakers and to examine the safety of both methods. We included patients undergoing single-chamber pacemaker implantation, either LP or TVP. Our outcomes were successful implantation rate, major complication, vascular injury, tamponade, and pneumothorax. We performed a double-arm analysis comparing LP versus TVP, with risk ratio (RR) and 95% confidence interval. A total of 10 studies were included in this meta-analysis. Regarding efficacy endpoints, RR revealed no significant difference between the LP and transvenous pacemaker groups in terms of successful rate of implantation (RR = 1.00; P = 0.77). Regarding safety outcomes, LP experienced lower incidence of major complications (RR = 0.47; P = 0.01), infection (RR = 0.24; P = 0.001), and tamponade (RR = 0.36; P = 0.01). There was no significant difference between both groups regarding pneumothorax (RR = 0.35; P = 0.22) and vascular injury (RR = 1.55; P = 0.25). The study findings suggest that both LPs and TVPs have similar effectiveness. Moreover, the incidences of pneumothorax, vascular injuries, and major complications were found to be comparable between the 2 methods. However, LPs were found to have lower rates of infection and tamponade.
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Habboush et al. (2024) conducted a meta-analysis in Single-chamber pacemaker implantation. Leadless pacemakers vs. Transvenous pacemakers was evaluated on Successful rate of implantation (RR 1.00, p=0.77). Leadless pacemakers had a similar successful implantation rate to transvenous pacemakers (RR 1.00; P=0.77), but were associated with lower rates of major complications (RR 0.47; P=0.01).
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