Key result
Niacin treatment increased serum adiponectin concentrations by 21% and attenuated obesity-induced adipose tissue inflammation in high-fat diet-fed mice in a receptor-dependent manner.
Why the study?
Does niacin increase adiponectin and decrease adipose tissue inflammation in a mouse model of obesity?
Does niacin increase adiponectin and decrease adipose tissue inflammation in a mouse model of obesity?
Effect estimate: 21% increase
Absolute Event Rate: 17.1% vs 14.1%
p-value: p=<0.05
Niacin attenuates obesity-induced adipose tissue inflammation and increases adiponectin in a niacin receptor-dependent manner in a mouse model.
No takes yet. Share an insight, caveat, or question.
Preclinical data only; leaves open whether niacin receptor agonism improves cardiometabolic outcomes in humans.
Wanders et al. (2013) studied Obesity-induced adipose tissue inflammation (n=54). Niacin vs. Vehicle (water) was evaluated on Serum adiponectin concentration (μg/ml) in high-fat diet-fed wild-type mice (21% increase, p=<0.05). Niacin treatment increased serum adiponectin concentrations by 21% and attenuated obesity-induced adipose tissue inflammation in high-fat diet-fed mice in a receptor-dependent manner.
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