Key result
Ross River virus can productively infect macrophages for over 50 days, with subneutralizing anti-RRV IgG showing classical antibody-dependent enhancement of infection.
Ross River virus can persistently infect macrophages, potentially facilitated by antibody-dependent enhancement, which may explain the pathogenesis of RRV-induced arthritis.
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In vitro macrophage RRV infection and IgG ADE require in vivo validation; leaves open their role in epidemic polyarthritis.
Linn et al. (1996) studied Ross River virus (RRV) infection / Epidemic polyarthritis. Ross River virus (RRV) and anti-RRV IgG was evaluated on Productive infection and antibody-dependent enhancement in macrophages. Ross River virus can productively infect macrophages for over 50 days, with subneutralizing anti-RRV IgG showing classical antibody-dependent enhancement of infection.
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