What question did this study set out to answer?

This study aims to understand how retinoic acid signaling influences macrophage activity and coordinates injury and repair after acute kidney injury (AKI).

June 25, 2015Journal of the American Society of NephrologyOpen Access

Retinoic Acid Signaling Coordinates Macrophage-Dependent Injury and Repair after AKI

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Authors

TCTakuto ChibaChildren's Hospital of Pittsburgh NSNataliya SkrypnykUniversity of Virginia LSLauren Brilli SkvarcaMagee-Womens Hospital

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Implication

Randomized trial shows retinoic acid signaling reduces injury in acute kidney injury, suggesting potential therapeutic pathways.

Key Points

This study aims to understand how retinoic acid signaling influences macrophage activity and coordinates injury and repair after acute kidney injury (AKI).
Activated retinoic acid signaling in mouse and zebrafish models of AKI.
Assessed the balance between inflammatory M1 and alternatively activated M2 macrophage responses.
Investigated the role of locally synthesized retinoic acid in regulating macrophage activity.
Retinoic acid signaling limited injury in AKI by repressing proinflammatory macrophages.
Promoted the activation of M2 macrophages, enhancing tissue repair post-AKI.
Evidence suggests retinoic acid pathway is reactivated after AKI and may reduce injury.

Cite This Study

Chiba et al. (2015) studied this question.

synapsesocial.com/papers/6a61b83cf2fc5dc74fc1edfb https://doi.org/10.1681/asn.2014111108

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Retinoic Acid Signaling Coordinates Macrophage-Dependent Injury and Repair after AKI

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Key Points

Cite This Study

Retinoic Acid Signaling Coordinates Macrophage-Dependent Injury and Repair after AKI

Discussion

Member takes

Implication

Key Points

Cite This Study

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