A Histopathological Spectrum, Descriptive Epidemiology and Survival Status of Ovarian Cancer Cases from a Tertiary Cancer Centre in Northern India: A Retrospective Cohort Study

Background: This work aims to evaluate the demographic profile, treatment patterns and survival outcomes of ovarian cancer (OC) patients at tertiary cancer centre in Bihar.Materials and methods: A retrospective study of ovarian cancer patients who were treated at Buddha Cancer Centre (BCC), Patna, between January 2019–December 2023. Detailed clinical history, tumor pathology, treatment modalities and survival outcomes of the patients were reviewed from clinical records. Response evaluation was done using clinical examination and computed tomography (CT) scan. Overall survival (OS) and progression-free survival (PFS) were calculated from time of diagnosis to time of death and from time of diagnosis to the time of progression. The statistical analysis was performed using Microsoft Excel. Kaplan–Meier plots were presented.Results: A total of (N = 437) histopathological confirmed OC cases data were reviewed retrospectively. Mean age ± SD (years): 55.7 ± 16.1 years (age range 18 years to over 60 years). Most cases were diagnosed at Stage III (n = 135; 30.89%) and Stage IV (n = 191; 43.71%) at the time of diagnosis. The most common histologic types were serous (52%) followed by mucinous (22%) and endometrioid (13%). The majority of patients had received chemotherapy and supportive regimen (n = 184; 42%), P value < 0.005. Mean OS ± SD (months) was 36.2 ± 31.9 and mean PFS ± SD (months) was 19.5 ± 24.5. Complete response (CR) was achieved in 19%, partial response (PR) in 16%, stable disease (SD) in 38%, and progressive disease (PD) in 43% of patients. Early-stage disease had a better survival rate (65.2%) while advanced stage had a poor outcome.Conclusion: Most OCs recur within 1.5 years. Mortality rates were associated with late stage of the disease clinically. Surgery followed by chemotherapy was associated with improved survival outcomes.