Key result
Left atrial appendage closure in patients with nonvalvular atrial fibrillation significantly decreased aldosterone levels at 12 months (209.04 vs 279.08 pg/ml, P=0.04).
Why the study?
The left atrial appendage has neuroendocrine function, but whether left atrial appendage closure affects neuroendocrine function in patients with nonvalvular atrial fibrillation remains unclear.
Does left atrial appendage closure affect neuroendocrine function in patients with nonvalvular atrial fibrillation?
Observational (n=20)
No
Does left atrial appendage closure affect neuroendocrine function in patients with nonvalvular atrial fibrillation?
Absolute Event Rate: 209.04% vs 279.08%
p-value: p=0.04
LAAC in patients with NVAF significantly reduces aldosterone levels at 12 months, suggesting an influence on the renin-angiotensin-aldosterone system.
BACKGROUND The left atrial appendage (LAA) is an organ with neuroendocrine function. It remains unclear whether left atrial appendage closure (LAAC) has physiological effects on neuroendocrine function in patients with nonvalvular atrial fibrillation (NVAF). In the present study, we aimed to investigate the effects of LAAC on neuroendocrine function in patients with NVAF. MATERIAL AND METHODS We enrolled 20 patients with NVAF treated by LAAC in Jiangsu Taizhou People's Hospital from October 2019 to October 2020. Blood samples were collected 1 day before LAAC and 12 months after LAAC. Plasma concentrations of adrenaline, aldosterone, pro-atrial natriuretic peptide (NT-proANP), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were measured. RESULTS LAAC was successfully performed in all patients, without serious complications. Compared with the preoperative levels, there was no significant difference in the levels of NT-proANP, NT-proBNP, and epinephrine at 12 months after LAAC (P>0.05). However, there was a significant decrease in aldosterone level at 12 months post-procedure (209.04±132.98 pg/ml) compared with pre-procedure baseline (279.08±166.88 pg/ml, P=0.04). There was no correlation between the compression rate of the occlusion and the reduction of aldosterone (Kendall's Tau-b=0.159, P=0.351). CONCLUSIONS LAAC can be safely and effectively performed in NVAF patients, and showed no significant effect on the adrenergic system and natriuretic peptides, but had an influence on the RAAS.
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Wang et al. (2022) conducted an observational in Nonvalvular atrial fibrillation (NVAF) (n=20). Left atrial appendage closure (LAAC) vs. Pre-procedure baseline was evaluated on Plasma concentration of aldosterone (p=0.04). Left atrial appendage closure in patients with nonvalvular atrial fibrillation significantly decreased aldosterone levels at 12 months (209.04 vs 279.08 pg/ml, P=0.04).
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