Key result
Heart failure is a frequent complication of diabetes with multifactorial pathophysiology, and its management currently relies on traditional cardiovascular risk reduction and ACE inhibitors.
This review highlights the multifactorial pathophysiology of heart failure in diabetic patients and emphasizes the need for clear guidelines on the diagnosis and management of these coexisting conditions.
Management of diabetic HF remains limited to risk reduction and ACE inhibitors; leaves open optimal strategies with newer agents.
Evidence from clinical trials repeatedly confirms the association of diabetes with heart failure, independent of hypertension, atherosclerosis, coronary artery disease and valvular heart disease. However, the importance of coexistence of diabetes and heart failure is not universally recognized, despite the fact that it may significantly contribute to morbidity and mortality of the diabetic population. It seems that prevention of heart failure, early diagnosis, and appropriate management could improve the outcome. Unfortunately, the etiology of heart failure in diabetic patients is still to be elucidated. It is multifactorial in nature and several cellular, molecular and metabolic factors are implicated. Additionally, there are still no definite guidelines on either the diagnosis and treatment of heart failure in diabetic patients or on the therapy of diabetes in subjects with heart failure. This review focuses on the pathophysiology, diagnosis, and prevention of heart failure in the diabetic population as well as management of both comorbidities.
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Kasznicki et al. (2014) conducted a review in Heart failure and diabetes mellitus. Heart failure is a frequent complication of diabetes with multifactorial pathophysiology, and its management currently relies on traditional cardiovascular risk reduction and ACE inhibitors.
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