What question did this study set out to answer?

The study aims to explore the immune responses generated by plasmid DNA injections encoding BHV-1 in mice and cattle.

September 1, 1993Journal of VirologyOpen Access

Bovine herpesvirus 1: immune responses in mice and cattle injected with plasmid DNA

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Randomized trial demonstrates immune responses to plasmid DNA in cattle, suggesting its potential as a vaccine method.

The study aims to explore the immune responses generated by plasmid DNA injections encoding BHV-1 in mice and cattle.
Mice and cattle were injected with plasmids encoding BHV-1 glycoproteins.
Immune responses were assessed through antibody titers and viral shedding.
Control groups were included for comparison.
Mice and cattle developed gene-specific antibody responses capable of neutralizing BHV-1.
Calves that received the plasmid encoding BHV-1 gIV exhibited higher antibody titers compared to control calves.
Vaccinated calves shed less virus after challenge than the control calf.

Cox et al. (1993) studied this question.

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