November 1, 2004The Journal of Clinical Endocrinology & Metabolism
Vitamin D₂Is Much Less Effective than Vitamin D₃in Humans
Key Points
- The study aimed to compare the potencies of vitamin D2 and D3 in raising serum 25-hydroxyvitamin D levels.
- Administered 50,000 IU doses of vitamin D2 and D3 to 20 healthy male volunteers.
- Measured serum vitamin D and 25-hydroxyvitamin D levels over 28 days.
- Calculated area under the curve for 25-hydroxyvitamin D concentration.
- Vitamin D2 yielded an area under the curve of 60.2 ng.d/ml, while vitamin D3 had 204.7 ng.d/ml (P < 0.002).
- The relative potency of vitamin D3 compared to D2 was calculated to be 9.5:1.
- Vitamin D2 showed a rapid decline in serum levels after initial rise, unlike vitamin D3, which peaked at 14 days.
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Implication
Randomized trial evaluates vitamin D2 and D3 efficacy in healthy males, revealing significant potency differences.
Cite This Study
Armas et al. (2004) studied this question.