Intensive blood pressure control in isolated systolic hypertension: a post hoc analysis of a cluster randomized trial

Figures

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  Fig. 1. Flowchart of the study. Abbreviations: SBP = systolic blood pressure; DBP = diastolic blood pressure; CRHCP = China Rural Hypertension Control Project. The randomization, recruitment, and enrollment of this study are shown.

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  Fig. 2. Systolic and diastolic blood pressure in the intervention and usual care groups over 36 months of follow-up. Notes: Error bars indicate 95% confidence intervals.

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  Fig. 3. Cumulative incidence of primary and secondary outcomes for intervention versus usual care. Abbreviations: CVD = cardiovascular disease; HR = hazard ratio. Cumulative incidence of primary outcome (a), stroke (b), myocardial infarction (c), heart failure (d), cardiovascular death (e), and all-cause death (f) for intervention versus usual care.

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  Fig. 4. Forest plot of the primary outcome according to subgroups. Abbreviations: CVD = cardiovascular disease; CI = confidence interval; DBP = diastolic blood pressure.

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  Fig. 5. Safety and renal outcomes by randomization groups. Abbreviations: CI = confidence interval; eGFR = estimated glomerular filtration rate; CKD = chronic kidney disease. Notes: Serious adverse events include deaths and hospitalizations in this analysis. Injurious falls was self-reported and defined as a fall that resulted in seeking medical care. Hypotension was defined as systolic blood pressure <90 mmHg at a village doctor visit or a study data a collection visit at months 6, 12, 18, 24, 30, and 36. Symptomatic hypotension was self-reported and confirmed by systolic blood pressure <90 mmHg a at a village doctor visit. Syncope was defined as self-reported temporary loss of consciousness that resulted in seeking medical care.