Key result
Suprarenal aortic coarctation induced left ventricular ANP and mRNA expression proportional to intraventricular pressure, which decreased upon release but ANP granules persisted up to 77 days.
Ventricular ANP gene expression and synthesis are dynamically regulated by intraventricular pressure, but the accumulation of ANP in overloaded ventricles is not an immediately reversible phenomenon.
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May guide ANP biomarker interpretation during ventricular overload relief; leaves open granule persistence relevance in human disease.
Gu et al. (1989) studied Overloaded left ventricle (n=60). Suprarenal aortic coarctation and release was evaluated on ANP immunoreactivity and ANP mRNA levels in the left ventricle. Suprarenal aortic coarctation induced left ventricular ANP and mRNA expression proportional to intraventricular pressure, which decreased upon release but ANP granules persisted up to 77 days.
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