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February 1, 1986Journal of Hypertension

Increased Concentration of Plasma Immunoreactive Atrial Natriuretic Factor in Dahl Salt Sensitive Rats with Sodium Chloride-Induced Hypertension

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Why the study?

Does a high-salt diet alter ANF concentrations in Dahl salt-sensitive and -resistant rats?

Population

Dahl salt-sensitive (S) and -resistant (R) rats

Comparison

High-salt diet for 7 weeks vs Low-salt diet for 7 weeks

Design

Preclinical

Follow-up

7 weeks

Authors

ITIssei TanakaHiroshima UniversityTITadashi InagamiHeart Failure / Cardiomyopathy

Discussion

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Implication

Indicates compensatory ANF response in salt-sensitive rat hypertension; leaves open human translation or therapeutic implications.

Structured PICO

Does a high-salt diet alter ANF concentrations in Dahl salt-sensitive and -resistant rats?

P
Population
Dahl salt-sensitive (S) and -resistant (R) rats
I
Intervention
High-salt diet for 7 weeks
C
Comparator
Low-salt diet for 7 weeks
O
Outcome
Immunoreactive ANF concentration in plasma, atrium, hypothalamus, and ponssurrogate

Plasma ANF is elevated in Dahl salt-sensitive rats with salt-induced hypertension, likely reflecting a compensatory mechanism to volume expansion.

Cite This Study

Tanaka et al. (1986) studied this question.

synapsesocial.com/papers/6a7e6606410afd830ac76fa5https://doi.org/10.1097/00004872-198602000-00017

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Atrial Natriuretic Factor in Sodium-Sensitive and Sodium-Resistant Dahl Rats1987 · 24 citations
  2. 2Dahl S rats have increased natriuretic factor in atria but are markedly hyporesponsive to it.1984 · 88 citations
  3. 3Atrial natriuretic factor in Dahl rats. Atrial content and renal and aortic responses.1985 · 46 citations
  4. 4Effects of chronic salt loading on plasma atrial natriuretic peptide (ANP) in the spontaneously hypertensive rat1987 · 12 citations
  5. 5Quantification of Messenger Ribonucleic Acid for Atrial Natriuretic Factor in Atria and Ventricles of Dahl Salt-Sensitive and Salt-Resistant Rats1987 · 9 citations