Key result
Salt loading in Dahl S rats decreased ANP-IR in the left atria and increased it in plasma and brain stem compared to control and Dahl R rats.
Why the study?
Does salt loading alter ANP-IR concentrations in Dahl S and Dahl R rats?
Does salt loading alter ANP-IR concentrations in Dahl S and Dahl R rats?
Salt loading alters the distribution of atrial natriuretic peptides in Dahl salt-sensitive rats, suggesting its involvement in salt-dependent hypertension.
In order to investigate the possible involvement of ANP in the salt dependent hypertension of the DS rats the concentrations of immunoreactive atrial natriuretic peptides (ANP-IR) in atria, plasma and brain of salt loaded and control fed DS and DR rats were determined. On a low salt diet the ANP-IR concentrations in atria, hypothalamus and basal ganglia of DS rats were higher versus DR rats. Salt loading results in a decrease of ANP-IR in left DS atria and an increase in plasma and brain stem of DS rat versus control and DR rat. The data are compared with other studies about ANP performed in Dahl rats, SHR and WKY rats. The possible reasons for the found distribution of ANP-IR are discussed.
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John et al. (1990) studied Salt dependent hypertension. Salt loading vs. Low salt diet / control fed was evaluated on Concentrations of immunoreactive atrial natriuretic peptides (ANP-IR) in atria, plasma and brain. Salt loading in Dahl S rats decreased ANP-IR in the left atria and increased it in plasma and brain stem compared to control and Dahl R rats.
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