February 1, 1987Journal of Hypertension
Atrial Natriuretic Factor in Sodium-Sensitive and Sodium-Resistant Dahl Rats
Population
Inbred (JR) strain of salt-sensitive Dahl (S) rats and normotensive salt-resistant Dahl (R) rats
Comparison
0.9% or 8% NaCl diets for up to 8 weeks, acute… vs Salt-resistant Dahl rats compared to…
Design
Preclinical
Follow-up
up to 8 weeks
Authors
Discussion
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Implication
ANF system does not drive salt-induced hypertension in Dahl rats; leaves open alternative pathways for targeted research.
Key Points
- To determine whether atrial natriuretic factor contributes to the onset or maintenance of chronic salt-induced hypertension in Dahl salt-sensitive rats compared to normotensive salt-resistant controls.
- Measured immunoreactive atrial natriuretic factor (ANF) in plasma and atria of inbred Dahl salt-sensitive (S) and salt-resistant (R) rats fed 0.9% or 8% NaCl diets for up to 8 weeks.
- Assessed plasma and atrial ANF responses to acute saline volume expansion in rats maintained on the 0.9% NaCl diet.
- Administered intravenous bolus injections of exogenous ANF (atriopeptin III) under both dietary salt conditions to assess blood pressure, renal blood flow, natriuresis, and glomerular filtration rate.
- Plasma and atrial ANF concentrations did not differ between Dahl S and R rats on either the 0.9% or 8% NaCl diet.
- Acute volume expansion elicited a 5- to 7-fold increase in plasma ANF in both S and R rats.
- Intravenous atriopeptin III produced equivalent transient blood pressure drops and pronounced increases in renal blood flow, glomerular filtration rate, and natriuresis in both strains.
Structured PICO
P
Population
Inbred (JR) strain of salt-sensitive Dahl (S) rats and normotensive salt-resistant Dahl (R) rats
I
Intervention
0.9% or 8% NaCl diets for up to 8 weeks, acute volume expansion, and exogenous ANF (atriopeptin III) intravenous bolus infusion
C
Comparator
Salt-resistant Dahl (R) rats compared to salt-sensitive Dahl (S) rats
O
Outcome
Plasma and atrial immunoreactive ANF valuessurrogate
The ANF system does not appear to play a significant role in the development or maintenance of chronic salt-induced hypertension in salt-sensitive Dahl rats.
Cite This Study
Sterzel et al. (1987) studied this question.