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May 1, 1989HypertensionOpen Access

Hyposecretion of atrial natriuretic factor by prehypertensive Dahl salt-sensitive rat.

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Population

Isolated heart-lung preparations of prehypertensive young and adult hypertensive inbred Dahl salt-sensitive…

Comparison

Preload-induced or afterload-induced atrial… vs Age-matched inbred Dahl salt-resistant rats

Design

Preclinical

Authors

MOMichael O. OnwocheiUniversity of Toledo Medical CenterJRJohn P. RappUniversity of Toledo

Discussion

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Implication

ANF hyposecretion in prehypertensive Dahl rats is hypothesis-generating for hypertension pathogenesis; clinical translation requires prospective human studies.

Structured PICO

P
Population
Isolated heart-lung preparations of prehypertensive young (6-8 weeks of age) and adult hypertensive (5-6 months of age) inbred Dahl salt-sensitive (SS/Jr) rats, and age-matched inbred Dahl salt-resistant (SR/Jr) rats.
I
Intervention
Preload-induced or afterload-induced atrial stretch
C
Comparator
Age-matched inbred Dahl salt-resistant (SR/Jr) rats
O
Outcome
Atrial natriuretic factor (ANF) releasesurrogate

Prehypertensive Dahl salt-sensitive rats exhibit hyposecretion of atrial natriuretic factor, suggesting a genetic trait relevant to the pathogenesis of hypertension that is later obscured by adaptive cardiac changes.

Cite This Study

Onwochei et al. (1989) studied this question.

synapsesocial.com/papers/6a6f92cc84cc45bb7bdfa3d0https://doi.org/10.1161/01.hyp.13.5.440
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Atrial natriuretic factor inhibits angiotensin-, norepinephrine-, and potassium-induced vascular contractility.1984 · 290 citations
  2. 2Quantification of Messenger Ribonucleic Acid for Atrial Natriuretic Factor in Atria and Ventricles of Dahl Salt-Sensitive and Salt-Resistant Rats1987 · 9 citations
  3. 3Atrial natriuretic factor in Dahl rats. Atrial content and renal and aortic responses.1985 · 46 citations
  4. 4INCREASED RIGHT OR LEFT ATRIAL PRESSURE STIMULATES RELEASE OF ATRIAL NATRIURETIC PEPTIDES IN CONSCIOUS DOGS1986 · 69 citations
  5. 5Atrial natriuretic factor causes specific relaxation of rat renal arcuate arteries1985 · 84 citations