Population
Renal papillary collecting tubule cells and glomerular mesangial cells from prehypertensive Dahl…
Comparison
Atrial natriuretic factor, Na nitroprusside, and… vs Dahl salt-resistant rat cells compared to Dahl…
Design
Preclinical
Authors
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Suggests ANF hyporesponsiveness contributes to salt-sensitive hypertension in rat models; leaves open relevance to human disease.
Reduced responsiveness to ANF in the papillary collecting duct of Dahl salt-sensitive rats may contribute to the development of salt-sensitive hypertension.
Appel et al. (1987) studied this question.
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