Why the study?
Does atriopeptin II increase single-nephron glomerular filtration rate in isolated perfused dog glomeruli?
Population
Isolated perfused dog glomerulus (n=6)
Comparison
Atriopeptin II added to perfusate at a final… vs Control period in the same isolated glomerulus
Design
Preclinical
Authors
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No immediate clinical implications; leaves open atriopeptin effects on glomerular hemodynamics in intact kidneys.
Does atriopeptin II increase single-nephron glomerular filtration rate in isolated perfused dog glomeruli?
Atriopeptin II increases single-nephron glomerular filtration rate in vitro by increasing glomerular capillary hydrostatic pressure and filtration fraction.
Fried et al. (1986) studied this question.
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