Why the study?
Does atrial natriuretic factor inhibit maximal tubuloglomerular feedback response in Munich-Wistar rats?
Population
16 Munich-Wistar rats
Comparison
Atrial natriuretic factor (ANF) administration vs Control period (before ANF administration)
Design
Preclinical
Authors
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Supports ANF effects on rodent renal autoregulation; leaves open translation to human glomerular hemodynamics.
Does atrial natriuretic factor inhibit maximal tubuloglomerular feedback response in Munich-Wistar rats?
Atrial natriuretic factor increases single nephron glomerular filtration rate by increasing glomerular capillary hydraulic pressure and blunting the maximal tubuloglomerular feedback response.
Huang et al. (1987) studied this question.