Key result
Intravenous administration of ANP in rats decreased renal net interstitial pressure and decreased tubuloglomerular feedback sensitivity, increasing the tubular flow rate for half-maximal Psf drop from 18.5 to 25.7 nl/min.
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No direct clinical implications; leaves open whether interstitial pressure mediates ANP effects on TGF in humans.
Absolute Event Rate: 25.7% vs 18.5%
Morsing et al. (1992) studied this question. Atrial natriuretic peptide (ANP) was evaluated on Tubular flow rate eliciting half the maximal drop in stop-flow pressure (Psf). Intravenous administration of ANP in rats decreased renal net interstitial pressure and decreased tubuloglomerular feedback sensitivity, increasing the tubular flow rate for half-maximal Psf drop from 18.5 to 25.7 nl/min.
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