Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 1, 1984Hypertension

Dahl S rats have increased natriuretic factor in atria but are markedly hyporesponsive to it.

View Full Paper
Ask AI
Bookmark
Share

Population

Dahl salt-sensitive (S) rats, salt-resistant (R) rats, and Sprague-Dawley (SD) recipients

Comparison

Atrial natriuretic factor administration and… vs Salt-resistant rats and low salt diet

Design

Preclinical

Follow-up

12 weeks

Authors

YHY HirataThe University of TokyoMGM C GanguliLTLouis TobianGeneral / Preventive / Lipids

Discussion

Loading...

Member takes

Implication

May indicate compensatory ANF upregulation in salt-sensitive models; leaves open whether ANF resistance contributes to human salt-sensitive hypertension.

Structured PICO

P
Population
Dahl salt-sensitive (S) rats, salt-resistant (R) rats, and Sprague-Dawley (SD) recipients
I
Intervention
Atrial natriuretic factor (ANF) administration and high salt (4% NaCl) diet
C
Comparator
Salt-resistant (R) rats and low salt (0.11% NaCl) diet
O
Outcome
Na excretion and atrial ANF contentsurrogate

Dahl salt-sensitive rats exhibit increased atrial natriuretic factor content but are hyporesponsive to its natriuretic effects compared to salt-resistant rats.

Cite This Study

Hirata et al. (1984) studied this question.

synapsesocial.com/papers/6a7e4b4e971946435f4f9b33https://doi.org/10.1161/01.hyp.6.2_pt_2.i148

Topics

Hypertension management
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Atrial Natriuretic Factor in Sodium-Sensitive and Sodium-Resistant Dahl Rats1987 · 24 citations
  2. 2Increased Concentration of Plasma Immunoreactive Atrial Natriuretic Factor in Dahl Salt Sensitive Rats with Sodium Chloride-Induced Hypertension1986 · 71 citations
  3. 3Atrial natriuretic factor in Dahl rats. Atrial content and renal and aortic responses.1985 · 46 citations
  4. 4Effects of salt loading on the fractional volume of atria‐specific granules in dahl salt‐sensitive and salt‐resistant rats1987 · 5 citations
  5. 5Papillary collecting tubule responsiveness to atrial natriuretic factor in Dahl rats.1987 · 21 citations