458P What is the impact of iatrogenic menopause on vaginal health and microbiome dynamics? Preliminary results of the menopause microbiome study

Genitourinary symptoms of menopause (GSM) such as vaginal dryness and irritation can be linked to changes in the vaginal microbiome. GSM are often even more severe in women with breast cancer (BC). Little is known about the timing of onset of vaginal changes and complaints of GSM during BC treatment and the relation of these changes towards for example sexual function. This study explores the vaginal health in premenopausal BC patients with an iatrogenic menopause. This first-in-time study collects longitudinal samples of vaginal microbiome during menopausal transition.