Key result
Indeterminate pulmonary nodules >1 cm were associated with increased risk of metastatic disease compared to subcentimeter nodules in renal cell carcinoma (HR 2.48; 95% CI 1.08-5.68; p=0.031).
Why the study?
Does the presence or size of indeterminate pulmonary nodules predict disease progression in patients with localized renal cell carcinoma?
Population
748 patients with localized renal cell carcinoma who had chest CT within 6 months before nephrectomy…
Comparison
Presence of indeterminate pulmonary nodules vs Absence of indeterminate pulmonary nodules, or…
Design
Cohort
Follow-up
median 4.1 years (IQR 2.2-6.1)
Authors
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Subcentimeter nodules should not alter surveillance in localized RCC; leaves open whether larger or multiple nodules predict progression.
Cohort (n=748)
Does the presence or size of indeterminate pulmonary nodules predict disease progression in patients with localized renal cell carcinoma?
Hazard Ratio: 2.48 (95% CI 1.08–5.68)
p-value: p=0.031
In patients with localized renal cell carcinoma, indeterminate pulmonary nodules less than 1 cm are not associated with disease progression, whereas nodules greater than 1 cm significantly predict metastatic disease.
Mano et al. (2014) conducted a cohort in Renal cell carcinoma (n=748). Indeterminate pulmonary nodules >1 cm vs. Subcentimeter indeterminate pulmonary nodules was evaluated on Metastatic disease (HR 2.48, 95% CI 1.08-5.68, p=0.031). Indeterminate pulmonary nodules >1 cm were associated with increased risk of metastatic disease compared to subcentimeter nodules in renal cell carcinoma (HR 2.48; 95% CI 1.08-5.68; p=0.031).
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