Key result
The 10-minute NASA lean test showed comparable systolic blood pressure changes to the head-up tilt table test (mean difference -0.7 mmHg), but yielded significantly higher DBP and HR changes.
Why the study?
The 10-minute NASA lean test was suggested for assessing abnormal hemodynamic responses in postacute COVID-19 syndrome, but no comparative study with the head-up tilt table test had been conducted.
Does the 10-minute NASA lean test alter blood pressure and heart rate responses compared to the head-up tilt table test in young individuals with postacute COVID-19 syndrome?
Cross-Sectional (n=80)
Does the 10-minute NASA lean test alter blood pressure and heart rate responses compared to the head-up tilt table test in young individuals with postacute COVID-19 syndrome?
The 10-minute NASA lean test is comparable to the head-up tilt table test for detecting systolic blood pressure changes in postacute COVID-19 syndrome, but yields higher diastolic blood pressure and heart rate responses.
Answers are grounded in this paper and cite their sources.
SBP responses appear comparable between NLT and HUTT in young PACS; leaves open whether NLT can substitute for HUTT in orthostatic evaluation.
BACKGROUND: Individuals with postacute COVID-19 syndrome (PACS) typically exhibit abnormal hemodynamic responses during upright positioning, including orthostatic hypotension and postural orthostatic tachycardia syndrome. The 10-minute NASA lean test (NLT) has been suggested for this condition. However, no comparative study with the head-up tilt table test (HUTT) has been conducted. This study aimed to compare blood pressure and heart rate responses during the 10-minute duration of NLT and HUTT. METHODS: Eighty young individuals (aged 22.0 ± 3.1 years) with PACS underwent both tests, with a 30-minute interval between tests. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) were measured every minute, and the differences between supine and upright positions were analyzed. RESULTS: There were no significant differences in SBP changes between HUTT and NLT (-7.8 ± 6.2 vs. -7.1 ± 7.5 mmHg) with a mean difference of -0.7 ± 9.0 mmHg. However, DBP changes were significantly lower in HUTT compared to NLT (-0.9 ± 6.4 vs. 1.5 ± 6.9 mmHg for NLT) with a mean difference of -2.4 ± 7.1 mmHg. Maximal HR was significantly lower in HUTT compared to NLT (92.0 ± 11.4 vs. 96.2 ± 10.8 bpm for NLT) with a mean difference of -4.2 ± 6.9 bpm. Additionally, HR changes were significantly lower in HUTT compared to NLT (21.5 ± 8.1 vs. 27.0 ± 9.0 bpm) with a mean difference of -5.4 ± 6.4 bpm. CONCLUSION: The NLT demonstrated comparability with the HUTT in detecting SBP changes. However, clinical applications should consider differences in measuring DBP and HR changes.
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Sathaporn et al. (2025) conducted a cross-sectional in postacute COVID-19 syndrome (PACS) (n=80). 10-minute NASA lean test (NLT) vs. head-up tilt table test (HUTT) was evaluated on Systolic blood pressure (SBP) changes between supine and upright positions (MD -0.7). The 10-minute NASA lean test showed comparable systolic blood pressure changes to the head-up tilt table test (mean difference -0.7 mmHg), but yielded significantly higher DBP and HR changes.
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