Population
Experimental LBBB dog model, patients with biventricular pacing devices, in vitro papillary muscle study…
Comparison
Assessment of pressures, myocardial deformation… vs Septum versus lateral wall
Design
Preclinical
Key result
During left bundle branch block, electromechanical delay was prolonged in the late-activated lateral wall compared to the septum (39 vs 11 ms, P=0.002) due to higher dP/dt at the time of activation.
Authors
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Prolonged EMD may contribute to LBBB inefficiency; leaves open whether targeting it improves CRT response.
Absolute Event Rate: 39% vs 11%
p-value: p=0.002
Prolonged electromechanical delay in late-activated myocardium during LBBB is caused by a higher dP/dt at the time of activation, suggesting that LV contractility modifies mechanical dyssynchrony.
Russell et al. (2011) studied Left bundle branch block (n=22). Late-activated left ventricular lateral wall vs. Septum was evaluated on Electromechanical delay (EMD) (p=0.002). During left bundle branch block, electromechanical delay was prolonged in the late-activated lateral wall compared to the septum (39 vs 11 ms, P=0.002) due to higher dP/dt at the time of activation.
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