Key result
A high triglyceride glucose index was independently associated with higher pulse wave velocity, indicating subclinical vessel disease in nondiabetic patients without cardiovascular disease.
Why the study?
Insulin resistance accelerates atherosclerosis, but the relationship between the triglyceride glucose index and functional vessel disease measured by pulse wave velocity needed evaluation in a nondiabetic asymptomatic population.
Is a high Triglyceride-Glucose (TyG) index associated with functional vessel disease (measured by PWV) in nondiabetic, asymptomatic patients?
Cross-Sectional (n=1,095)
Is a high Triglyceride-Glucose (TyG) index associated with functional vessel disease (measured by PWV) in nondiabetic, asymptomatic patients?
The Triglyceride-Glucose (TyG) index is independently associated with subclinical vessel disease (measured by PWV) in healthy, nondiabetic individuals, suggesting its utility as an early marker for atherosclerosis risk.
May flag early arterial stiffness in asymptomatic nondiabetics; leaves open causal links and need for prospective validation.
Insulin resistance is one of the most important risk factors that accelerate atherosclerosis. The goal of this study is to investigate the relationship between the triglyceride glucose (TyG) index and functional vessel disease measured using pulse wave velocity (PWV), in a nondiabetic asymptomatic Turkish population. Nondiabetic, healthy patients (n = 1095) with no previous history of coronary heart disease were enrolled. Functional vessel disease was detected by measuring PWV. The TyG index was calculated using the following equation: log [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. The study population was divided into 2 groups based on their TyG index. The high TyG index group had higher PWV, corrected PWV, left ventricular mass index, body mass index, rates of hypertension, and was predominately male. Age, gender, blood urea nitrogen level, and TyG index were detected as independent risk factors of PWV in linear regression analysis. Triglyceride glucose index and age were also independent risk factors of the corrected PWV in logistic regression analysis. These findings show a relationship between TyG index and subclinical vessel disease, even in patients without a history of atherosclerotic cardiovascular disease or diabetes.
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Baydar et al. (2021) conducted a cross-sectional in Subclinical atherosclerosis (n=1,095). High triglyceride glucose (TyG) index vs. Low triglyceride glucose (TyG) index was evaluated on Functional vessel disease measured using pulse wave velocity (PWV). A high triglyceride glucose index was independently associated with higher pulse wave velocity, indicating subclinical vessel disease in nondiabetic patients without cardiovascular disease.
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