Key result
Hypercholesterolaemia in dogs with suspect acute pancreatitis was significantly correlated with increased ALP (r=0.498, p<0.001) and GGT activities, suggesting an association with cholestasis.
Why the study?
The association between hyperlipidaemia and acute pancreatitis is unknown in dogs.
Is hypercholesterolaemia associated with cholestatic markers in dogs with suspect acute pancreatitis?
Observational (n=74)
Is hypercholesterolaemia associated with cholestatic markers in dogs with suspect acute pancreatitis?
Effect estimate: r = 0.498
p-value: p=<0.001
In dogs with suspect acute pancreatitis, cholesterol concentration is positively correlated with ALP and GGT activities, suggesting an association between cholestasis and hypercholesterolaemia.
Hyperlipidaemia–pancreatitis link in dogs remains unproven; leaves open whether lipid control alters risk or outcomes.
The association between hyperlipidaemia and acute pancreatitis is unknown in dogs. This study aimed to investigate the association between hyperlipidaemia and other markers of cholestasis in dogs with suspect acute pancreatitis. Case records of dogs with suspect acute pancreatitis were retrospectively reviewed. Dogs that had pre-existing disorders or drug therapies associated with hyperlipidaemia, hypocholesterolaemia, or incomplete biochemical data were excluded. In total, 74 dogs met the inclusion criteria. There were 33 (44.6%) dogs with hypercholesterolaemia (HC) and 41 (55.4%) without (NC). Increased triglyceride concentrations were significantly (p = 0.005) more common in HC dogs (n = 13, 39.4%) compared with NC dogs (n = 4, 9.8%), but no value exceeded 5 mmol/L. The ALP activity was significantly higher in the HC group compared to NC group (932 (461–7271) and 380 (135–1312) IU/L, respectively, p = 0.001). There was a moderate positive correlation between cholesterol concentration and ALP activity (r = 0.498, p < 0.001) and a weak positive correlation between cholesterol concentration and gamma-glutamyl transferase activity (r = 0.296, p = 0.011). Cholesterol concentration was correlated with ALP and GGT activities suggesting an association between cholestasis and hypercholesterolaemia in dogs with acute pancreatitis.
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Silva et al. (2024) conducted an observational in Suspect acute pancreatitis in dogs (n=74). Hypercholesterolaemia vs. Normocholesterolaemia was evaluated on Correlation between cholesterol concentration and ALP activity (r = 0.498, p=<0.001). Hypercholesterolaemia in dogs with suspect acute pancreatitis was significantly correlated with increased ALP (r=0.498, p<0.001) and GGT activities, suggesting an association with cholestasis.
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