Key result
The S-rat renin allele was associated with an approximate 10 mmHg increase in blood pressure for one dose and a 20 mmHg increase for two doses in an F2 rat population.
Why the study?
Does the S-rat renin allele increase blood pressure in Dahl rats?
Does the S-rat renin allele increase blood pressure in Dahl rats?
This study provides definitive evidence that the renin gene, or a closely linked gene, regulates blood pressure in the rat model.
Answers are grounded in this paper and cite their sources.
Should not change practice; leaves open renin gene relevance to human hypertension.
Blood pressure is influenced by multiple genetic loci whose identities are largely unknown. A restriction fragment length polymorphism (RFLP) in the renin gene was found between Dahl salt-hypertension-sensitive (S) and Dahl salt-hypertension-resistant (R) rats. In an F2 population derived from crossing S and R rats, the renin RFLP cosegregated with blood pressure. One dose of the S-rat renin allele was associated with an increment in blood pressure of approximately 10 mmHg, and two doses of this allele increased blood pressure approximately 20 mmHg. From this it can be definitively concluded that in the rat the renin gene is, or is closely linked to, one of the genes regulating blood pressure.
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Rapp et al. (1989) studied Blood pressure. S-rat renin allele vs. R-rat renin allele (zero doses of S-rat allele) was evaluated on Blood pressure (10 mmHg increase per dose of S-rat renin allele). The S-rat renin allele was associated with an approximate 10 mmHg increase in blood pressure for one dose and a 20 mmHg increase for two doses in an F2 rat population.
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