Key result
Lentivirus-mediated gene transfer in the guinea pig cochlea resulted in restricted transduction limited to the periphery of the perilymphatic space, with intact tissue architecture and no inflammation.
Lentivirus-mediated gene transfer in the cochlea results in restricted transduction at the periphery of the perilymphatic space without causing inflammation, making it potentially suitable for producing secreted gene products.
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Supports safe lentiviral cochlear delivery in guinea pigs; leaves open transduction optimization before clinical translation.
Han et al. (1999) studied this question. Lentivirus-GFP was evaluated on Lentivirus transduction and expression of GFP. Lentivirus-mediated gene transfer in the guinea pig cochlea resulted in restricted transduction limited to the periphery of the perilymphatic space, with intact tissue architecture and no inflammation.
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