Key result
Uncomplicated Type 1 diabetes mellitus was associated with significantly impaired flow-mediated dilatation compared to controls (3.95% vs 7.75%, P<0.001).
Why the study?
Are flow-mediated dilatation and microvascular reactivity impaired in patients with uncomplicated Type 1 diabetes mellitus compared to controls?
Population
40 patients with uncomplicated Type 1 diabetes mellitus and 32 controls (n=72)
Comparison
B-mode and Doppler ultrasound scanning of the… vs Controls (n=32)
Design
Case-control
Authors
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Supports further investigation of DSS in FMD assessment for DM; should not yet alter clinical practice.
Observational (n=72)
Are flow-mediated dilatation and microvascular reactivity impaired in patients with uncomplicated Type 1 diabetes mellitus compared to controls?
Absolute Event Rate: 3.95% vs 7.75%
p-value: p=<0.001
Impaired flow-mediated dilatation in Type 1 diabetes is multifactorial, driven by reduced diastolic shear stress and microcirculatory dysfunction rather than solely diminished nitric oxide bioavailability.
Lockhart et al. (2011) conducted an observational in Uncomplicated Type 1 diabetes mellitus (n=72). Type 1 diabetes mellitus vs. Controls was evaluated on Flow-mediated dilatation (FMD) (p=<0.001). Uncomplicated Type 1 diabetes mellitus was associated with significantly impaired flow-mediated dilatation compared to controls (3.95% vs 7.75%, P<0.001).
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