Key result
Particulate matter exposure drives cardiopulmonary harm via direct translocation, neural pathways, and local inflammation.
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The effects of particulate matter (PM) on cardiopulmonary health have been studied extensively over the past three decades. Particulate matter is the primary criteria air pollutant most commonly associated with adverse health effects on the cardiovascular and respiratory systems. The mechanisms by which PM exerts its effects are thought to be due to a variety of factors which may include, but are not limited to, concentration, duration of exposure, and age of exposed persons. Adverse effects of PM are strongly driven by their physicochemical properties, sites of deposition, and interactions with cells of the respiratory and cardiovascular systems. The direct translocation of particles, as well as neural and local inflammatory events, are primary drivers for the observed cardiopulmonary health effects. In this review, toxicological studies in animals, and clinical and epidemiological studies in humans are examined to demonstrate the importance of using all three approaches to better define potential mechanisms driving health outcomes upon exposure to airborne PM of diverse physicochemical compositions.
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Pinkerton et al. (2019) conducted a review in Adverse cardiopulmonary health effects. Airborne particulate matter (PM) was evaluated. Airborne particulate matter exposure drives adverse cardiopulmonary health effects through direct particle translocation, neural mechanisms, and local inflammatory events.
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