Key result
In two patients with Wolff-Parkinson-White syndrome, His bundle electrograms revealed ventricular pre-excitation due to a bypass tract, and both were successfully treated with propranolol and a pacemaker.
Population
2 patients with Wolff-Parkinson-White (pre-excitation) syndrome and long histories of paroxysmal arrhythmias
Design
Case_series
Authors
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Supports accessory pathway theory in WPW; leaves open validation and therapeutic translation in larger cohorts.
Case Report (n=2)
Early electrophysiological study using His bundle recordings demonstrated that WPW pre-excitation bypasses the His bundle, and highlighted successful management with propranolol and demand pacing.
Castellanos et al. (1970) conducted a case report in Wolff-Parkinson-White (Pre-excitation) Syndrome (n=2). Oral propranolol and implanted demand pacemaker was evaluated. In two patients with Wolff-Parkinson-White syndrome, His bundle electrograms revealed ventricular pre-excitation due to a bypass tract, and both were successfully treated with propranolol and a pacemaker.
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