Key result
NRP1 and ACE2 expressions are upregulated in kidney renal clear cell and papillary cell carcinomas compared to healthy conditions, and significantly correlate with KIRC patient survivability.
Why the study?
Both NRP1 and ACE2 are expressed in the kidney and associated with renal diseases, but their expression profiles and impact on survival in KIRC and KIRP were not established.
Observational
High expression of NRP1 and ACE2 in renal carcinomas may increase the risk of SARS-CoV-2 infection and affect survivability in these patients.
Neuropilin-1 (NRP1) is a recently identified glycoprotein that is an important host factor for SARS-CoV-2 infection. On the other hand, angiotensin-converting enzyme-2 (ACE2) acts as a receptor for SARS-CoV-2. Additionally, both NRP1 and ACE2 express in the kidney and are associated with various renal diseases, including renal carcinoma. Therefore, the expression profiles of NRP1 and ACE2 in kidney renal clear cell carcinoma (KIRC) and kidney renal papillary cell carcinoma (KIRP) patients from the various cancer databases were investigated along with their impact on patients' survivability. In addition, coexpression analysis of genes involved in COVID-19, KIRC, and KIRP concerning NRP1 and ACE2 was performed. The results demonstrated that both t NRP1 and ACE2 expressions are upregulated in KIRC and KIRP compared to healthy conditions and are significantly correlated with the survivability rate of KIRC patients. A total of 128 COVID-19-associated genes are coexpressed, which are positively associated with NRP1 and ACE2 both in KIRC and KIRP. Therefore, it might be suggested that, along with the ACE2, high expression of the newly identified host factor NRP1 in renal carcinomas may play a vital role in the increased risk of SARS-CoV-2 infection and survivability of COVID-19 patients suffering from kidney cancers. The findings of this investigation will be helpful for further molecular studies and prevention and/or treatment strategies for COVID-19 patients associated with renal carcinomas.
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Hossain et al. (2021) conducted an observational in Kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), and COVID-19. NRP1 and ACE2 expression vs. Healthy conditions was evaluated on Expression levels and survivability rate. NRP1 and ACE2 expressions are upregulated in kidney renal clear cell and papillary cell carcinomas compared to healthy conditions, and significantly correlate with KIRC patient survivability.
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