Key result
18F-FDG PET is currently the method of choice for evaluating brown adipose tissue, showing promise for managing obesity and type 2 diabetes, though further multicentric trials are needed.
Why the study?
The role of brown adipose tissue activity quantification using [18F] FDG is not completely understood.
How is 18F-FDG PET/CT technology used for the assessment and quantification of brown adipose tissue activity?
How is 18F-FDG PET/CT technology used for the assessment and quantification of brown adipose tissue activity?
18F-FDG PET remains the primary imaging modality for assessing brown adipose tissue, which may have therapeutic implications for metabolic disorders.
Supports BAT quantification as metabolic biomarker; leaves open clinical adoption pending prospective validation.
Introduction This review provides an update of 18 F-fluorodeoxyglucose ([18F] FDG) for Brown adipose tissue (BAT) activity quantification, whose role is not completely understood.Areas covered We conducted an unstructured search of the literature for any studies employing the [18F] FDG PET in BAT assessment. We explored BAT quantification both in healthy individuals and in different pathologies, after cold exposure and as a metabolic biomarker. The assessment of possible BAT modulators by using [18F] FDG PET is shown. Further PET tracers and novel developments for BAT assessments are also described.Expert opinion Further PET tracers and imaging modalities are under investigation, but the [18F] FDG PET is currently the method of choice for the evaluation of BAT and further multicentric trials are needed for a better understanding of the BAT physiopathology, also after cold stimuli. The modulation of BAT activity, assessed by [18F] FDG PET imaging, seems a promising tool for the management of conditions such as obesity and type 2 diabetes. Moreover, an interesting possible correlation of BAT activation with prognostic [18F] FDG PET indices in cancer patients should be assessed with further multicentric trials.
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Ricci et al. (2023) conducted a review in Brown adipose tissue (BAT) activity. 18F-FDG PET/CT was evaluated. 18F-FDG PET is currently the method of choice for evaluating brown adipose tissue, showing promise for managing obesity and type 2 diabetes, though further multicentric trials are needed.
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