Key result
Elevated red cell distribution width was an independent predictor of nonvalvular atrial fibrillation in both low altitude (OR 1.687; 95% CI 1.021-2.789) and high altitude (OR 1.755; 95% CI 1.179-2.613).
Why the study?
Data were limited on the relationship between red cell distribution width, altitude, and subtypes of atrial fibrillation.
Is red cell distribution width (RDW) associated with nonvalvular atrial fibrillation and its subtypes in low and high altitude populations?
Population
303 patients with nonvalvular AF (156 at low altitude, 147 at high altitude) and control subjects
Comparison
Low altitude vs high altitude, and paroxysmal AF vs persistent AF vs control subjects
Design
Observational cross-sectional study
Authors
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Altitude-related RDW differences in AF subtypes are hypothesis-generating; prospective studies needed before clinical relevance.
Observational (n=303)
Is red cell distribution width (RDW) associated with nonvalvular atrial fibrillation and its subtypes in low and high altitude populations?
Odds Ratio: 1.687 (95% CI 1.021–2.789)
p-value: p=<0.05
Elevated red cell distribution width is an independent risk marker for nonvalvular atrial fibrillation, with levels further increased by the persistent AF subtype and high altitude exposure.
Han et al. (2019) conducted an observational in Nonvalvular atrial fibrillation (n=303). Elevated red cell distribution width vs. Control subjects was evaluated on Presence of atrial fibrillation (OR 1.687, 95% CI 1.021-2.789, p=<0.05). Elevated red cell distribution width was an independent predictor of nonvalvular atrial fibrillation in both low altitude (OR 1.687; 95% CI 1.021-2.789) and high altitude (OR 1.755; 95% CI 1.179-2.613).
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