Key result
Long-stay ICU patients exhibited significantly decreased quadriceps rectus femoris muscle area compared to healthy controls (OR per cm2 0.07; 95% CI 0.012-0.41).
Why the study?
There is currently no standardized procedure to assess sarcopenia in long-stay catabolic patients.
Does a novel ultrasound protocol identify differences in quadriceps rectus femoris muscle characteristics in long-stay ICU patients compared to healthy controls?
Observational (n=48)
Does a novel ultrasound protocol identify differences in quadriceps rectus femoris muscle characteristics in long-stay ICU patients compared to healthy controls?
Odds Ratio: 0.07 (95% CI 0.012–0.41)
p-value: p=≤ 0.001
A novel ultrasound protocol can detect significant differences in quadriceps rectus femoris muscle area and central tendon thickness in long-stay ICU patients compared to healthy controls.
Ultrasound may detect ICU muscle changes; leaves open whether protocol improves monitoring or outcomes.
There is currently no standardized procedure to assess sarcopenia in long-stay catabolic patients. Our aim is to analyze a novel ultrasound muscle assessment protocol in these patients versus healthy controls, by carrying out a prospective observational study. We designed a new ultrasound protocol that assesses quadriceps rectus femoris (QRF) muscle quality in real-time B-mode, color-Doppler, and M-mode ultrasound, and evaluates QRF intramuscular central tendon thickness, cross-sectional area, and muscle thickness in ultrasound B-mode. Logistic regression was performed as a multivariable analysis on 29 cases and 19 controls. The QRF muscle area and thickness were shown to significantly decrease (p ≤ 0.001), and the central tendon thickness significantly increased (p = 0.047) in cases versus controls. The QRF muscle echogenicity and angiogenic activity fasciculations, subcutaneous edema, and intramuscular fluid were also significantly different between the two groups (p < 0.001). The selected variables in the multivariate logit analysis were the muscle area (OR per cm2 = 0.07; 95% confidence interval (CI) = 0.012–0.41) and the central tendon thickness (OR per mm 1.887; 95% CI = 2.66–13.38).
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Hernández-Socorro et al. (2018) conducted an observational in Sarcopenia in long-stay ICU patients (n=48). Long-stay ICU admission vs. Healthy controls was evaluated on Quadriceps rectus femoris muscle area (OR 0.07, 95% CI 0.012-0.41, p=≤ 0.001). Long-stay ICU patients exhibited significantly decreased quadriceps rectus femoris muscle area compared to healthy controls (OR per cm2 0.07; 95% CI 0.012-0.41).
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